论文部分内容阅读
本文应用酶谱法,观察了正常月经周期及IUD异常出血时子宫内膜.经5h组织块培养后分泌的MMPs.结果可见月经周期的三个不同阶段MMPs的表达明显不同.与增生期及分泌期酶活性比较,月经期酶活性及种类显著增加.IUD异常出血时,多种MMPs的活性明显低于正常月经期.结果提示置IUD后引起的月经期延长和出血量增加可能与子宫内膜中MMPs酶量减少及其活性降低有关.
In this paper, the application of zymography to observe the normal menstrual cycle and abnormal endometrial bleeding in IUD endometrial tissue secreted after 5h MMPs results showed that the three different stages of the menstrual cycle, MMPs expression was significantly different with the proliferation and secretion During the period of menstrual period, the activities and types of enzymes increased significantly.The activity of various MMPs was significantly lower than that of normal menstruation during the abnormal bleeding of IUD.The results suggest that the prolonged menstrual period and the increased bleeding may be associated with endometrial In the reduction of MMPs enzyme and its activity decreased.