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目的探讨老年高血压病患者与骨质疏松症(OP)及血清维生素D水平的关系。方法老年体检者403例中,患高血压病的224例(A组),血压正常者179例(B组)。比较两组血压、骨密度和血清25-羟维生素D[25-(OH)D]水平,分析A组患者骨密度及血清25-(OH)D与其他因素的相关性。结果 A组OP患病率高于B组(45.1%vs.35.2%)(P<0.05)。A组腰椎、股骨颈、Ward’s三角和股骨大转子的骨密度均低于B组(P<0.01)。A组血清25-(OH)D水平低于B组[(23.31±10.17)nmol/L vs.(30.26±12.68)nmol/L](P<0.01)。Pearson相关分析显示,A组腰椎骨密度与SBP、脉压水平呈负相关(r=-0.121、-0.117,P<0.01);其血清25-(OH)D与年龄、SBP、DBP、脉压水平亦呈负相关(r=-0.022、-0.118、-0.091、-0.116,P<0.05)。结论合并高血压病的老年患者血清25-(OH)D水平降低,发生OP的风险增加。
Objective To investigate the relationship between osteoporosis (OP) and serum vitamin D levels in elderly patients with essential hypertension. Methods Among 403 elderly patients, 224 cases of hypertension (group A) and 179 cases of normal blood pressure (group B). The blood pressure, bone mineral density and serum 25-hydroxyvitamin D [25- (OH) D] levels in the two groups were compared to analyze the correlation between bone mineral density and serum 25- (OH) D in group A and other factors. Results The prevalence of OP in group A was higher than that in group B (45.1% vs.35.2%, P <0.05). The BMD of lumbar spine, femoral neck, Ward’s triangle and femoral greater trochanter in group A were lower than those in group B (P <0.01). The level of serum 25- (OH) D in group A was lower than that in group B [(23.31 ± 10.17) nmol / L vs. (30.26 ± 12.68) nmol / L], P <0.01. Pearson correlation analysis showed that the lumbar BMD of group A was negatively correlated with SBP and pulse pressure (r = -0.121, -0.117, P <0.01). The serum 25- (OH) D and age, SBP, DBP, The levels were also negatively correlated (r = -0.022, -0.118, -0.091, -0.116, P <0.05). Conclusion Serum 25- (OH) D levels are lower in elderly patients with hypertension and the risk of developing OP is increased.