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消化系统肿瘤与多种肿瘤相关基因的异常表达密切相关,Gankyrin是一种癌基因,于肝癌、结直肠癌、胰腺癌等消化系统肿瘤中高表达,并通过依赖泛素的蛋白酶解系统介导多种转录因子、细胞周期调控蛋白以及抑癌蛋白如p53、Rb等的降解。研究表明,Gankyrin在消化系统肿瘤形成及细胞的生长周期调控中发挥重要作用,在消化系统肿瘤的早期诊断及判断预后方面具有一定的应用前景,同时也可能成为消化系统肿瘤基因治疗的潜在靶点。
Digestive system tumors are closely related to the abnormal expression of many tumor-associated genes. Gankyrin is an oncogene that is overexpressed in digestive system tumors such as liver, colorectal, and pancreatic cancers and is mediated by ubiquitin-dependent proteolytic systems Transcription factors, cell cycle regulatory proteins, and tumor suppressor proteins such as p53, Rb and other degradation. Studies have shown that Gankyrin plays an important role in digestive system tumor formation and cell cycle regulation. It has some potential applications in the early diagnosis and prognosis of digestive system tumors, and may also be a potential target for gene therapy of digestive system tumors .