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过去40年,从动物和人动脉硬化获得的资料,认为钙化是粥样硬化混合病变纤维性复盖(fibrous capping)的晚期结果,与早期的增生病变无必然的联系.因此强调对本病病因进行多变量分析,包括脂蛋白的分解代谢,内皮损伤或通透性改变,血小板的作用和平滑肌细胞增生的介体,巨噬细胞功能和脂
In the past 40 years, data from animal and human atherosclerosis suggest that calcification is an advanced outcome of fibrous capping of mixed lesions of atherosclerosis and is not necessarily associated with an early proliferative lesion, so emphasis is placed on the etiology of the disease Multivariate analyzes were performed including lipoprotein catabolism, endothelial injury or permeability changes, platelet function and mediators of smooth muscle cell proliferation, macrophage function and lipid