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本文报告用马桑内酯阈下剂量反复注入家兔海马内造成点燃性发作。通过预先埋植的套管向海马内分别注入不同剂量的马桑内酯稀释液2μl,以相同容量的生理盐水作对照,每日注射一次。用多导生理仪遥测记录海马电和皮层电,同时观察行为。结果表明,点燃效应一旦建立,动物除有诱发性发作外,其中2只还有自发性发作。点燃效应平均保留58天。点燃效应模型可用于系统观察抗癫痫药物的疗效和癫痫发病机理的研究。
This article reports that repeated injections of the sublingual dose of coriaria lactone into the rabbit hippocampus cause ignitant seizures. Two μl of different doses of the dilute solution of corigenin was injected into the hippocampus through a previously implanted cannula, and the same volume of physiological saline was used as a control and injected once a day. The multi-channel physiological instrument was used to remotely record hippocampal electrical and cortical electricity and observe behavior. The results showed that, once the igniting effect was established, animals had spontaneous seizures in addition to induced seizures. The lighting effect remains on average for 58 days. The lighting effect model can be used to systematically observe the efficacy of antiepileptic drugs and the study of epileptogenesis.