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回顾研究1977～1986年确诊为阴道上皮内瘤样变(VIN)的94例患者,对其中74例随访,进行单因素和多因素分析评价危险因素。21例病损小而集中,活检后自然缓解;9例阴道镜下用活检镜切除;44例给予化学手术治疗,即在局部5-Fu治疗几天后,部分瘤变上皮脱落,然后用机械方法或低功率(10W)的电子手术器械完全切除经治疗的瘤变上皮,而不损伤基质,避免疤痕形成。治疗结局是缓解、复发后缓解或发展为浸润阶段。分析如下危险因素:多灶性、肛门生殖道瘤变综合征、相关的宫颈瘤变、VIN病理分级、免疫抑制、放疗史和子宫切除史。
A total of 94 patients with vaginal intraepithelial neovascularization (VIN) diagnosed between 1977 and 1986 were retrospectively studied. Among them, 74 patients were followed up for risk factors by univariate and multivariate analysis. Twenty-one cases were small and concentrated, and were naturally relieved after biopsy. Nine cases underwent colposcopy with biopsy and 44 cases were treated with chemical surgery. After several days of topical 5-Fu treatment, some neoplasms became epithelial shedding, Methods or low-power (10 W) electronic surgical instruments completely excised the treated neoplastic epithelium without damaging the stroma and avoiding scarring. Treatment outcome is remission, remission or development of infiltration stage. Analysis of the following risk factors: multifocal, anal reproductive tract neoplasia syndrome, related cervical neoplasia, VIN pathological grade, immunosuppression, radiotherapy history and history of hysterectomy.