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小肠的钙吸收随年龄增长而降低,很可能是导致年龄有关的骨丢失的重要致病因素。维生素D及其代谢产物对小肠正常钙吸收是极为重要的。维生素D受损状态(根据25-二羟维生素D(25-OHD)和天然维生素D的低血清浓度)和1,25-二羟维生素D[1,25-(OH)_2D]肾原性产生能力不足被认为是老年人小肠钙吸收低的参与因素。为研究年龄、生活条件和中等量维生素D补给对老年人维生素D状态的影响,作者将两组长期生活于老年协会的老年人(一组补给维生素D400IU,另一组则否)25-OHD血清浓度同一组住于家中有活动的老年人及一组青中年成人对比。为调查维生素D代谢年龄依赖性受损的可能性,作者对比了同组受检者1,25-OH)_2D和24,25-二羟维生素D[24.25-(oH)_2D]
Calcium absorption in the small intestine decreases with age and is likely to be an important causative agent of age-related bone loss. Vitamin D and its metabolites on the normal intestinal absorption of calcium is extremely important. Vitamin D impaired status (based on low serum concentrations of 25-dihydroxyvitamin D (25-OHD) and native vitamin D) and renal origin of 1,25-dihydroxyvitamin D [1,25- (OH) Insufficient capacity is thought to be a contributing factor in the low intestinal absorption of calcium in the elderly. To investigate the effects of age, living conditions and moderate vitamin D supplementation on the vitamin D status of the elderly, the authors compared two groups of older adults living in geriatric society (one vitamin D 400 IU for one group and 25-OHD serum for another) Concentration of the same group of active elderly living in the home and a group of middle-aged adult contrast. To investigate the possibility of age-dependent vitamin D metabolism impairment, the authors compared 1,25-OH) 2D and 24,25-dihydroxyvitamin D [24.25- (oH) _2D]