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目的 :获取本地区正常人群鼻咽部肺炎链球菌携带情况 ,为疾病预防和治疗提供科学依据。方法 :随机抽检正常人群 (按防疫人群监测共分四组 :2～ 4岁、6～ 8岁、9～ 12岁、2 5～ 39岁组 )鼻咽拭子进行培养、分离、鉴定及药敏试验 ,按《全国临床检验操作规程》进行。结果 :2 6 7例标本共分离出 71株肺炎链球菌 ,分离率为 2 6 .6 %。 2～ 4岁组检出 18株 ,检出率 2 5 .8% ;6～ 8岁检出 2 0株 ,检出率 37.0 % ;9～ 12岁组检出 2 2株 ,检出率 2 9.3% ;2 5～ 39岁组检出 11株 ,检出率 16 .2 %。各年龄组鼻咽部肺炎链球菌反携带率经 χ2检验 ,χ2 =7.110 .0 5相差无显著性意义 ,少年儿童组合并后肺炎链球菌的携带率 2 9.6 % (5 9/ 199)与成人组 17.6 % (12 / 6 8)相比较经 χ2检验 ,χ2 =5 .0 7>P0 .0 5( 1 ) =3.84 ,差异有显著性。耐青霉素肺炎链球菌为 2 6 .8%。结论 :本地区正常人群鼻咽部肺炎链球菌携带率为 2 6 .6 % ,少年儿童鼻咽部携带率较成人高。对青霉素耐药率处于较高水平 ,耐青霉素菌株对其他常用抗生素普遍耐药 ,且已发现对三代头孢菌素耐药菌株
OBJECTIVE: To obtain the prevalence of Streptococcus pneumoniae in the nasopharynx of the normal population in this area and provide a scientific basis for disease prevention and treatment. Methods: Random sampling of normal population (according to the epidemic prevention population monitoring is divided into four groups: 2 to 4 years old, 6 to 8 years old, 9 to 12 years old, 25 to 39 years old group) nasopharyngeal swab for culture, isolation, identification and medicine Min test, according to “National Clinical Laboratory Procedures”. Results: Totally 71 strains of Streptococcus pneumoniae were isolated from 267 specimens with a separation rate of 26.6%. 18 strains were detected in 2 ~ 4 years old group, the detection rate was 25.8%; 20 strains were detected in 6 ~ 8 years old, the detection rate was 37.0%; 22 strains were detected in 9 ~ 12 years group, the detection rate was 2 9.3%; 11 out of 25 to 39 years old group, the detection rate was 16.2%. Each age group nasopharyngeal Streptococcus pneumoniae anti-carrier rate by χ2 test, χ2 = 7.11 0.05 The difference was not significant, juvenile children combined with Streptococcus pneumoniae (P <0.01). The carriage rate of 29.6% (59/199) was significantly higher than that of the adult group (17.6%, 12/68) byχ2 test . Penicillin-resistant Streptococcus pneumoniae was 26.8%. Conclusion: The prevalence of Streptococcus pneumoniae in nasopharynx of normal population in this area is 26.6%, and that of children and adolescents is higher than that of adults. Penicillin resistance rates at a high level, resistant to penicillin strains commonly resistant to other commonly used antibiotics, and has been found on the third-generation cephalosporin-resistant strains