论文部分内容阅读
[目的]探讨应用小剂量As2O3联合化疗治疗急性早幼粒细胞白血病(APL)的临床疗效、毒副反应及机制。[方法]31例初发APL患者,应用As2O35mg加入生理盐水500ml中静脉滴注,1次/d,每次持续3～5h,连续4周为1个疗程或连续用药直至完全缓解。治疗期间检测血常规,对WBC>10×109/L患者同时加用小剂量化疗。[结果]29例达CR,总缓解率达93.5%,中位缓解时间23(17～33)d。1例因颅内出血死亡,1例未缓解。5例(16.1%)出现消化道反应,6例(19.4%)出现肝功能损害。[结论]小剂量As2O3联合化疗治疗APL缓解率高,毒副反应小。
[Objective] To investigate the clinical efficacy, side effects and mechanism of low dose As2O3 combined with chemotherapy in the treatment of acute promyelocytic leukemia (APL). [Method] 31 cases of newly diagnosed APL patients were treated with 500ml of As2O35mg intravenous infusion of normal saline once a day for 3 ~ 5h every four weeks for 1 course or continuous treatment until complete remission. During the treatment of blood tests, WBC> 10 × 109 / L patients plus small doses of chemotherapy. [Results] 29 patients achieved CR, the total remission rate was 93.5%, the median remission time 23 (17 ~ 33) d. 1 patient died of intracranial hemorrhage, 1 patient did not relieve. Gastrointestinal reactions occurred in 5 cases (16.1%) and liver damage occurred in 6 cases (19.4%). [Conclusion] The low dose As2O3 combined with chemotherapy is effective in treating APL with low toxicity.