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时辰药理学研究发现,一些疾病如心绞痛、高血压、哮喘、炎症反应及疼痛等的发作具有时间节律性,传统的以零级速率、一级速率释药的缓/控释释药技术只能使药物在不易发病的时段内维持一定的血药浓度,而到需要药物起到预防和治疗作用时,体内药物浓度却又达不到所要求的水平,从而延误了有效治疗时机。因此,这几类释药技术制备的制
Time pharmacology study found that some diseases such as angina pectoris, hypertension, asthma, inflammation and pain episodes have time rhythm, the traditional zero-rate, a rate of release of sustained release / controlled release drug technology can only So that the drug is not easy to maintain the period of time to maintain a certain plasma concentration, and to the need for drugs to play a preventive and therapeutic effect, the body’s drug concentration but can not reach the required level, thus delaying the effective timing of treatment. Therefore, these types of release preparation technology