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目的探讨应用普贝生促宫颈成熟后对各个产程、产后出血及围产儿结局的影响。方法将有指证终止妊娠的200例宫颈未成熟足月妊娠孕妇随机分为2组,研究组采用普贝生置阴道促宫颈成熟,24h后如未临产予催产素引产。对照组直接采用催产素引产。比较有完整产程产妇的各个产程时间,产后出血情况及两组的新生儿结局情况。结果研究组的第一产程平均(6.86±3.02h)明显短于对照组的(11.38±2.47h),两者有显著性差异(P<0.05)。而两组间总产程、第二、第三产程时间及产后出血量无明显差异(P>0.05)。研究组新生儿的的高胆红素血症率明显低于对照组,两者有显著性差异(P<0.05),而两组间胎窘率、新生儿窒息率、转科率均无明显统计学意义(P>0.05)。结论应用普贝生促宫颈成熟后临产后能有效缩短第一产程,降低新生儿的高胆红素血症发生率,而对产妇产后出血发生率及其他围产儿结局等并无影响。
Objective To investigate the effects of applying Przewalski’s cervical ripening on the various stages of labor, postpartum hemorrhage and perinatal outcome. Methods A total of 200 pregnant women with term pregnancy without pregnancy were divided into two groups at random. The study group was treated with pueraria vaginal to promote cervical ripening. After 24 hours, no induced labor was given oxytocin. The control group used oxytocin directly. Comparison of full labor maternal labor time, postpartum hemorrhage and two groups of neonatal outcomes. Results The average length of the first stage of labor (6.86 ± 3.02h) in the study group was significantly shorter than that in the control group (11.38 ± 2.47h), with significant difference (P <0.05). There was no significant difference between the two groups in the total production process, the second and third stage of labor and the amount of postpartum hemorrhage (P> 0.05). The incidence of hyperbilirubinemia in neonates in the study group was significantly lower than that in the control group (P <0.05), but there was no significant difference between the two groups in the rates of fetal distress, neonatal asphyxia and conversion rate Statistical significance (P> 0.05). CONCLUSION: Przewalski ’s application of Przewalski’ s cervical ripening may shorten the first stage of labor and reduce the incidence of hyperbilirubinemia in newborns. However, it has no effect on the incidence of postpartum hemorrhage and other perinatal outcomes.