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手足口病(HFMD)具有传染性强、发病率高的特点。2008年,我国局部地区爆发HFMD疫情,重症患儿的致死致残率高,引起全社会的高度关注。流行病学调查显示病原体主要为肠道病毒71型(EV71)和柯萨奇A16病毒,尤其是感染EV71后危害更重〔1〕。EV71有显著地神经嗜异性〔2〕,易侵犯脑干及其周围组织导致脑干脑炎和神经源性肺水肿,病情进展迅速,可致神经系统后遗症甚至死亡。因此,如何早期识别重症HFMD,并阻断病
Hand, foot and mouth disease (HFMD) is contagious and has a high incidence. In 2008, the outbreak of HFMD in some areas of our country caused severe morbidity and mortality in critically ill children, arousing great concern of the whole society. Epidemiological studies have shown that pathogens are mainly Enterovirus 71 (EV71) and Coxsackie A16 virus, especially after EV71 infection more harmful (1). EV71 has significantly neurotropic (2), easy to infringe the brainstem and its surrounding tissue leading to brainstem encephalitis and neurogenic pulmonary edema, the rapid progress of the disease can cause nervous system sequelae and even death. Therefore, how to identify severe HFMD early and block the disease