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目的探讨米索前列醇联合缩官素对预防产后出血的效果。方法选取我院2006年1月至2011年6月490例产妇,将其随机分成两组研究组和对照组,每组孕妇245例。对照组在分娩胎儿后立刻静脉注射10U缩宫素,研究组在分娩胎儿后在立刻注射缩宫素的时候,在肠壁处放0.4mg米索前列醇片。仔细记录两个小组第3产程所需要的时间、产后24h出血量及血压、脉搏的变化。结果研究组第3产程时间和24h出血量比对照组都少,差异都具有统计学意义(P<0.05);两组孕妇在使用药物前后测量的脉搏、血压发生的变化比较都没有统计学意义(P>0.05)。结论缩宫素及米索前列醇联合使用可以预防产后出血,而这也是一种相对安全、有效和简便的临床方法。
Objective To investigate the effect of misoprostol combined with reduced allosteric on the prevention of postpartum hemorrhage. Methods 490 maternal women from January 2006 to June 2011 in our hospital were selected and randomly divided into two groups, study group and control group, with 245 pregnant women in each group. In the control group, 10 U oxytocin was administered intravenously immediately after the fetus was delivered. When the oxytocin group was injected immediately after the fetus was born, the study group placed 0.4 mg of misoprostol in the intestinal wall. Carefully record the time required for the two groups of the third stage of labor, postpartum hemorrhage and blood pressure, pulse changes. Results Compared with the control group, the time of the third stage of labor and the amount of bleeding of 24h were less in the study group than in the control group (P <0.05). There was no significant difference in the changes of pulse and blood pressure between the two groups before and after using the drugs (P> 0.05). Conclusion The combination of oxytocin and misoprostol can prevent postpartum hemorrhage, which is also a relatively safe, effective and simple clinical method.