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老年wister大鼠随机分为 5组 :正常对照组 ;补硒组 (0 .5mg/kg) ;有氧运动 +补硒组 ;有氧运动组 ;大强度运动组 ,观察 5周。结果表明 :补硒组、补硒 +有氧运动组、心肌脂质过氧化水平明显下降 ,同时GSH -Px活性明显升高 ,CuZn -SOD活性变化不明显。有氧运动组CuZn -SOD酶活性明显上升。GSH -PX活性变化不明显。大强度运动组脂质过氧化水平明显升高 ,CuZn -SOD酶及GSH -Px活性有下降趋势 ,血清GOT活性明显升高。补硒组、有氧运动组GOT变化不明显。表明有氧运动可提高心肌细胞抗氧化酶活性 ,从而有效防止自由基损伤 ,延缓器官衰老 ,补硒同时进行有氧运动效果更好。大强度运动由于自由基大量生成 ,破坏了抗氧化酶活性 ,产生自由基损伤导致心肌细胞破损。
The aged wister rats were randomly divided into 5 groups: normal control group, selenium-supplemented group (0.5 mg / kg), aerobic exercise + selenium-supplemented group, aerobic exercise group, and intensive exercise group for 5 weeks. The results showed that the level of myocardial lipid peroxidation decreased significantly in selenium-supplemented group, selenium-supplemented + aerobic exercise group, while the activity of GSH-Px was significantly increased while the activity of CuZn-SOD was not significantly changed. Aerobic exercise group CuZn-SOD activity was significantly increased. GSH-PX activity was not significantly changed. Intensive exercise group lipid peroxidation levels were significantly increased CuZn-SOD activity and GSH-Px activity decreased, serum GOT activity was significantly increased. Selenium group, aerobic exercise group GOT change was not obvious. Aerobic exercise can increase myocardial antioxidant enzyme activity, thus effectively preventing free radical damage, slowing organ aging, supplementation of selenium aerobic exercise at the same time better. High-intensity exercise due to a large number of free radicals, destroyed the antioxidant enzyme activity, resulting in free radical damage leading to myocardial cell damage.