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目的 观察高氟环境作业工人服用海尔福口服液前后血清生化指标的变化 ,以验证其防治效果。方法 口服海尔福 1 5天 ,每天 3次 ,测定服药前后血清丙氨酸氨基转移酶 (ALT)活性和丙二醛 (MDA)、血清氟离子 (F- )及钙、磷等含量。结果 服药后血清ALT活力、MDA含量明显下降 (P <0 .0 0 1 ) ;血F- 下降不明显 (P >0 .0 5) ;钙含量下降 ,磷含量升高 (P <0 .0 0 1 ) ,但仍在正常范围内。结论 海尔福口服液对高氟环境作业工人有明显保护肝脏功能和抗氧化作用
Objective To observe the changes of serum biochemical indexes before and after taking Hailufu oral liquid in workers with high fluorine environment to verify its control effect. Methods Serum levels of alanine aminotransferase (ALT), malondialdehyde (MDA), serum fluoride (F-), calcium, phosphorus and other contents were measured before and after taking oral Herfalox® once daily for 15 days. Results After treatment, serum ALT activity and MDA content were significantly decreased (P <0.01); blood F-drop was not significant (P> 0.05); calcium content decreased, phosphorus content increased 0 1) but still within normal range. Conclusion Heierfu oral liquid has obvious protection on liver function and anti-oxidation in workers with high fluorine environment