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目的探讨不同类型冠心病(CHD)患者血浆B型钠尿肽(BNP)的水平变化及其临床意义。方法:选取稳定型心绞痛(SAP)患者30例、不稳定型心绞痛(UAP)患者30例、急性心肌梗死(AMI)患者25例,健康体检者30例作为对照组,采用微粒子酶免分析法检测上述研究对象的BNP水平,Gensini评分系统评价冠脉造影的结果。统计分析CHD不同组别的BNP水平变化及其与Gensini评分系统的相关性。结果 BNP浓度在AMI组为(1278.2±1759.2)pg/ml,UAP组(272.4±352.8)pg/mL,SAP组(71.6±97.5)pg/mL,对照组(40.2±61.1)pg/mL,对照组和SAP组的BNP浓度差异无统计学意义(P>0.05),AMI组高于UAP组(P<0.05),UAP组BNP浓度明显高于SAP组(P<0.05)。不同Gensini积分组之间血浆BNP浓度水平也呈上升趋势,且三组间血清BNP浓度差异有统计学意义(P<0.05)。结论 BNP水平与冠心病临床严重程度,心肌缺血严重程度具相关性。
Objective To investigate the changes of plasma B-type natriuretic peptide (BNP) in patients with different types of coronary heart disease (CHD) and its clinical significance. Methods: Thirty patients with stable angina pectoris (SAP), 30 patients with unstable angina pectoris (UAP), 25 patients with acute myocardial infarction (AMI) and 30 healthy controls were enrolled as the control group. The BNP level of the above study, Gensini scoring system to evaluate the results of coronary angiography. Statistical analysis of different groups of CHD BNP level changes and its correlation with Gensini scoring system. Results BNP concentrations in the AMI group were (1278.2 ± 1759.2) pg / ml, 272.4 ± 352.8 pg / mL in the UAP group, 71.6 ± 97.5 pg / mL in the SAP group and 40.2 ± 61.1 pg / mL in the control group There was no significant difference in BNP concentration between SAP group and SAP group (P> 0.05). AMI group was higher than UAP group (P <0.05). BNP concentration in UAP group was significantly higher than that in SAP group (P <0.05). Plasma BNP concentrations also showed an upward trend among different Gensini scores, and there was a significant difference in serum BNP concentrations between the three groups (P <0.05). Conclusion The level of BNP is correlated with the clinical severity of coronary heart disease and the severity of myocardial ischemia.