垂体前叶功能减退性闭经的促排卵治疗

• 作 者: 陈晓燕 毛文军 曹缵孙
• 机 构: 西安医科大学第一附属医院生殖内分泌研究室,西安医科大学第一附属医院生殖内分泌研究室,西安医科大学第一附属医院生殖内分泌研究室 西安 710061,西安 710061,西安 710061
• 出 处: 陕西医学杂志
• 发表日期: 1996年07期
• 关键词: 促排卵治疗 促性腺激素类 治疗周期 OHSS 激素替代治疗 闭经患者 闭经/药物疗法 治疗应用 诱发排卵 黄体功能

应用国产hMG-hCG治疗4例垂体前叶功能减退性闭经患者,共12个治疗周期,均促排卵成功,1例单胎妊娠,1例3胎妊娠,胎儿全部存活。3个治疗周期发生卵巢过度刺激综合征(Ovarian hyperstimulation syndrome,OHSS),其中2个周期为中度,1个周期为轻度。结果提示:在hMG治疗前应给予雌-孕激素替代治疗3个周期以上;诱发排卵成败的关键是选择最佳的时机使用hCG;排卵后应继续使用小剂量hCG或孕酮维持黄体功能;同时应重视OHSS的防治。

Four domestic hMG-hCG patients were treated with hMG-hCG for a total of 12 cycles, all of which had successful ovulation induction. One case of singleton pregnancy and one case of 3-fetus pregnancy all survived. Ovarian hyperstimulation syndrome (OHSS) occurred in three cycles, of which two were moderate and one was mild. The results suggest that: before hMG treatment should be given estrogen-progesterone replacement therapy more than three cycles; the key to the success or failure of ovulation is to choose the best time to use hCG; ovulation should continue to use low-dose hCG or progesterone to maintain luteal function; Should pay attention to the prevention and treatment of OHSS.