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目的观察常规疗法加单硝酸异山梨醇治疗慢性肺源性心脏病的临床疗效。方法将100例肺心病失代偿期患者随机分成两组,对照组50例使用吸氧、抗感染、氨茶碱、必嗽平、改善通气等常规治疗;治疗组50例在常规治疗基础上加用单硝酸异山梨醇50mg口服,1次/d,连用2周。观察两组治疗前后的心电图ST-T及血气分析变化并加以分析。结果治疗组在治疗前后自身对照并与对照组比较心电图ST-T抬高,动脉血PaO2增加、PaCO2减少均明显优于治疗前及对照组,其差异有统计学意义(P<0.05)。结论单硝酸异山梨醇能恢复患者的心电图ST-T,改善患者的心功能,同时改善患者的肺循环及动脉血气,具有可靠的治疗作用。
Objective To observe the curative effect of conventional therapy plus isosorbide mononitrate on chronic cor pulmonale. Methods 100 cases of decompensated pulmonary heart disease were randomly divided into two groups, the control group of 50 cases using oxygen, anti-infection, aminophylline, cough, improve ventilation and other conventional treatment; treatment group of 50 patients on the basis of routine treatment Plus isosorbide mononitrate 50mg orally, 1 / d, once every 2 weeks. Before and after treatment, ECG ST-T and blood gas analysis changes were observed and analyzed. Results Compared with the control group, ST-T elevation, arterial blood PaO2 and PaCO2 reduction in the treatment group before and after treatment were significantly higher than those before treatment and in the control group (P <0.05). Conclusion Isosorbide mononitrate can restore the electrocardiogram of patients with ST-T, improve the patient’s cardiac function, and improve the patient’s pulmonary circulation and arterial blood gas, with a reliable therapeutic effect.