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目的:探讨彩色多普勒超声联合检测血清附睾蛋白4(HE4)、糖类抗原125(CA125)在临床上诊断卵巢癌中的应用价值。方法:采用酶联免疫吸附法检测86例卵巢癌患者术前HE4与CA125的水平,结合卵巢癌患者的临床特点与彩超检查结果,并与手术结果及临床病理诊断作对照分析。结果:彩超诊断的准确率为87.2%,HE4与CA125诊断的准确率分别为72.1%与75.6%,三者联合诊断的准确率可达97.7%。结论:术前采用多普勒超声联合HE4与CA125检查可以有效提高术前诊断卵巢良恶性肿瘤的准确性,为患者制定合理的治疗方案提供依据。
Objective: To investigate the clinical value of color Doppler ultrasound in the detection of serum epididymal protein 4 (HE4), carbohydrate antigen 125 (CA125) in the diagnosis of ovarian cancer. Methods: The levels of preoperative HE4 and CA125 in 86 patients with ovarian cancer were detected by enzyme-linked immunosorbent assay (ELISA). The clinical features and the results of color Doppler ultrasonography in patients with ovarian cancer were analyzed. The results were compared with the surgical findings and clinicopathological diagnosis. Results: The diagnostic accuracy of color Doppler ultrasound was 87.2%. The diagnostic accuracy of HE4 and CA125 were 72.1% and 75.6% respectively. The diagnostic accuracy of the three methods was 97.7%. Conclusion: Preoperative Doppler ultrasound combined with HE4 and CA125 examination can effectively improve the accuracy of preoperative diagnosis of benign and malignant ovarian tumors, provide a basis for patients to develop a reasonable treatment.