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(口匹)呋氨苄青霉素(Pivampicillin)是氨苄青霉素的酯化物,在体内迅速水解成氨苄青霉素,因此二者抗菌谱和活性相同。但前者口服吸收更好,同剂量的血浓度比氨苄青霉素高2～3倍,服后1小时达到高峰,从尿中排泄也较多,故对尿路感染有显著疗效。作者用上述二药对慢性支气管炎伴急性发作病例作10天疗程的疗效比较。共选出住院男病人66例,均患慢性支气管炎多年,近来有急性化脓性发作。用单盲法随机给药,34例用氨苄青霉素,每日4次,共2克,32例用(口匹)呋氨苄青霉素,每日4次共1克。观察:①24小时痰量及分4级记录其脓性程度。②全身
(Oral) Furose ampicillin (Pivampicillin) is ampicillin esterification of the rapid hydrolysis in vivo into ampicillin, so the two antimicrobial spectrum and activity of the same. However, the former oral absorption better, with the same dose of blood concentration 2 to 3 times higher than that of ampicillin, 1 hour after serving to peak, excrete more urine, so the urinary tract infection has a significant effect. The author of the above two drugs in patients with chronic bronchitis and acute exacerbation of the 10-day course of treatment compared. A total of 66 cases of hospitalized male patients were selected, all suffering from chronic bronchitis for many years, recent acute suppurative seizures. Randomly administered by single-blind method, 34 cases with ampicillin, 4 times a day, a total of 2 grams, 32 cases with (oral) furosemide penicillin, 4 times a total of 1 gram. Observation: ① 24-hour sputum volume and grade 4 recorded the degree of purulence. ② whole body