论文部分内容阅读
为探讨人类乳头状瘤病毒致幼儿喉鳞状上皮乳头状瘤的病原学及形态学特点 ,分析 HPV与 P5 3在肿瘤表达的临床意义 ,采用免疫组化 PV90 0 0法 ,检测了 47例次儿童喉乳头状瘤标本 HVP6/ 11亚型、HPV16亚型及 P5 3蛋白在肿瘤中的表达水平 ,结合肿瘤的不典型增生及凹空细胞的形成进行了综合分析。结果显示 ,幼年型喉乳头状瘤 HPV感染有以 HPV16感染为主 ,P5 3的高表达是肿瘤增殖活跃的特征之一 ,肿瘤的不典型增生发生率较高 ,并可能是肿瘤复发的病原学基础
To investigate the etiological and morphological characteristics of laryngeal squamous cell carcinoma of the human papillomavirus (HPV) in young children and to analyze the clinical significance of HPV and P53 expression in the tumor, immunohistochemical PV90 0 0 method was used to detect 47 cases The expression of HVP6 / 11 subtype, HPV16 subtype and P5 3 protein in children with laryngeal papilloma were analyzed in combination with atypical hyperplasia of tumor and the formation of concave cells. The results showed that HPV16 infection was the predominant HPV infection in juvenile laryngeal papilloma. P5 3 overexpression was one of the features of active tumor proliferation. The incidence of atypical hyperplasia of tumor was high and may be the etiology of tumor recurrence basis