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目的观察缬沙坦对降低房颤患者卒中发生率及血管内皮功能的影响。方法选取2013年1月-2015年1月青县人民医院心内科所收治的心房颤动患者120例,随机分为治疗组与对照组各60例。2组均接受抗凝、降血脂等常规对症治疗,在此基础上,对照组予氨氯地平治疗,治疗组予缬沙坦治疗。比较2组脑卒中发生率及NO与ET检测值以及血管内皮功能变化。结果治疗组发生脑卒中3例(5.00%)明显低于对照组的9例(15.00%)。差异有统计学意义(P<0.05)。治疗前2组NO、ET与FMD值比较差异无统计学意义(P>0.05);治疗后2组NO水平与FMD均呈上升趋势,ET水平下降,且治疗组改善程度优于对照组,2组比较差异有统计学意义(P<0.05)。结论缬沙坦可有效改善内皮功能,降低脑卒中发生率,值得临床推广应用。
Objective To observe the effect of valsartan on reducing the incidence of stroke and endothelial function in patients with atrial fibrillation. Methods A total of 120 patients with atrial fibrillation admitted from January 2013 to January 2015 in Qingxian People’s Hospital were randomly divided into treatment group (60 cases) and control group (60 cases). Both groups received conventional symptomatic treatment such as anticoagulation and hypolipidemic treatment. On the basis of this, the control group was treated with amlodipine, and the treatment group was treated with valsartan. The incidence of stroke and the changes of NO and ET and the changes of vascular endothelial function were compared between the two groups. Results Three cases (5.00%) of the stroke patients in the treatment group were significantly lower than the control group (15.00%). The difference was statistically significant (P <0.05). There was no significant difference in NO, ET and FMD between the two groups before treatment (P> 0.05). After treatment, NO and FMD in both groups showed an upward trend and ET level decreased, and the improvement in the treatment group was better than that in the control group. 2 The difference was statistically significant (P <0.05). Conclusion Valsartan can effectively improve endothelial function and reduce the incidence of stroke, which is worthy of clinical application.