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  5. Targeting histones for degradation in cancer cells as a novel strategy in cancer treatment

Targeting histones for degradation in cancer cells as a novel strategy in cancer treatment

来源 :中国科学:生命科学英文版 | 被引量 : 0次 | 上传用户：magicMan555
【摘 要】
：
The anticancer therapies with the joint treatment of a histone deacetylase(HDAC) inhibitor and a DNA-damaging approach are actively under clinical investigation
【作 者】
：
Yesheng Yin Qianqian Zhu Tianx 
【机 构】
：
CollegeofLifeSciences,KeyLaboratoryofCellProliferationandRegulationBiology
【出 处】
：
中国科学:生命科学英文版
【发表日期】
：
2019年8期
【关键词】
：
HDAC HISTONE DEACETYLASE inhibitor DNA damage ANTICANCER agent HISTONE DEGRADATI 
【基金项目】
：
supported by the National Natural Science Foundation of China(31530014,91319303,31600626).
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The anticancer therapies with the joint treatment of a histone deacetylase(HDAC) inhibitor and a DNA-damaging approach are actively under clinical investigations, but the underlying mechanism is unclear. Histone homeostasis is critical to genome stability
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