Effects of Heavy Ion Irradiation on Cell Survival and Cell Cycle Delays in Synchronous SMMC-7721 Hep

• 出 处: IMP & HIRFL Annual Report
• 发表日期: 2005年00期
• 关键词: hepatoma synchronized progression exposure cycle strand DNA protect break expose

Ionizing radiation produces various kinds of damage, for example, DNA double- or single-strand break, and base damage. Cellular responses after ionizing radiation exposure can be considered to protect the cells from the radiation-induced damage. The purpose of this study is to investigate and compare cell survival and cell cycle progression in human hepatoma cells (SMMC-7721) synchronized at G0/C1,G1/S and G2/M phases, respectively.

Ionizing radiation produces various kinds of damage, for example, DNA double- or single-strand break, and base damage. Cellular responses after ionizing radiation exposure can be considered to protect the cells from the radiation-induced damage. The purpose of this study is to investigate and compare cell survival and cell cycle progression in human hepatoma cells (SMMC-7721) synchronized at G0 / C1, G1 / S and G2 / M phases, respectively.