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目的:分析并研究克拉霉素治疗鼻咽癌放疗后并发鼻窦炎患者的临床效果。方法:选取佛山市高明区中医院在2014年2月至2015年6月收治56例鼻咽癌放疗后1年并发鼻窦炎的患者,所有患者按照随机法分为观察组和对照组,均给予常规治疗,对照组配合阿奇霉素进行治疗,观察组配合克拉霉素治疗,对两组的治疗效果观察并比较。结果:观察组患者的治疗有效率为92.86%,对照组的治疗有效率为89.29%,组间比较,差异无统计学意义(P>0.05);对两组患者治疗前后的CT影响情况和VAS评分情况进行观察并作比较,治疗后均明显改善,但观察组患者的改善情况更为明显,差异具有统计学意义(P<0.05)。结论:临床上对于鼻咽癌放疗后出现鼻窦炎的患者,在常规治疗的基础上配合克拉霉素予以治疗,患者治疗后的CT改善更好,且患者的疼痛更轻。
Objective: To analyze and study the clinical effect of clarithromycin in the treatment of nasopharyngeal carcinoma patients with sinusitis after radiotherapy. Methods: From June 2014 to June 2015, 56 patients with sinusitis with nasopharyngeal carcinoma one year after radiation therapy were selected from the Gaoming District Chinese Medicine Hospital of Foshan City. All patients were divided into observation group and control group according to randomization Routine treatment, the control group with azithromycin treatment, observation group with clarithromycin treatment, the treatment effect of the two groups were observed and compared. Results: The effective rate of treatment in observation group was 92.86%, and that in control group was 89.29%. There was no significant difference between two groups (P> 0.05). The influence of CT before and after treatment and VAS Scores were observed and compared, after treatment were significantly improved, but the observation group patients improved more significantly, the difference was statistically significant (P <0.05). CONCLUSIONS: Clinically, for patients with nasosinusitis after radiotherapy for nasopharyngeal carcinoma, patients treated with clarithromycin on the basis of routine treatment have better CT and lighter pain after treatment.