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目的考察发育性口吃成年人是否具有异常脑结构改变,探讨其相关的神经机制。方法应用 GE Haifa 2T 高场强 MR 成像系统,对10例发育性口吃成年人和12名非口吃成年人行全脑扫描,用快速梯度回波成像序列获得三维结构图像。采用以 SPM99软件为基础的 VBM 软件包,由计算机全自动地进行数据处理,比较两组间脑局部灰质的差异。结果口吃组双侧大脑半球颞上回、颞中回、中央后回、顶下小叶和运动前回的灰质明显高于对照组(P<0.001),左、右侧半球增加的体素数分别为48 782个和60 247个;而双侧小脑后叶和延髓明显少于对照组(P<0.001),减少的体素总数为32 394个。结论发育性口吃成年人在脑组织结构上与非口吃成年人有所不同。其中,双侧小脑及延髓灰质体积减少,可能是口吃者言语运动协调障碍的主要神经解剖学基础;而双侧半球中灰质体积增加的脑区,则可能是对言语协调功能不足进行长期代偿所致的结构性变化。
Objective To investigate whether stuttering adults have abnormal brain structure changes and to explore their related neural mechanisms. Methods The GE Haifa 2T high-field MR imaging system was used to perform whole-brain scanning on 10 strabismus adults and 12 non-stuttering adults. Three-dimensional structural images were obtained by rapid gradient echo imaging. Using SPM99 software-based VBM software package, the data was processed automatically by the computer, and the differences of brain gray matter were compared between the two groups. Results The gray matter in the temporal gyrus, the middle temporal gyrus, the posterior gyrus, the inferior parietal lobe and the anteroposterior return of the bilateral cerebral hemispheres in the stuttering group were significantly higher than those in the control group (P <0.001), and the increasing numbers of voxels in the left and right hemispheres were 48 782 and 60 247, respectively. However, the posterior lobes and medulla oblongata of the bilateral cerebellum were significantly less than those of the control group (P <0.001), with a decrease of 32 394 voxels. Conclusion Developmental stuttering adults differ from non-stuttering adults in brain tissue structure. Among them, bilateral cerebellar and medulla oblongata mass reduction may be the main neuroanatomical basis of stunned speech movement disorders in strabismus; and bilateral brain regions with increased volume of gray matter in the hemisphere may be compensated for long-term compensation for speech coordination deficiencies Due to the structural changes.