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各种炎症反应时,白细胞介素—6(IL—6)诱导肝细胞中各种急性期蛋白的产生且最先出现,可以对新生儿感染症做出早期诊断。对象和方法1990年5月～7月出生的244名新生儿为观察对象,199名健康儿为对照组,其中发热38℃以上的有57名。从分娩后胎盘侧脐带采血,部分病例同时采集产妇的外周血,之后分高血清,保持在—80℃,用酶标记免疫吸附法测定IL—6浓度。结果(1)脐血中IL—6浓度:健康小儿血清IL—6大部分不高,只1例超过5pg/ml(0.5%)。脐血中5pg/ml以上者占18%,其中8例为50pg/ml以上,(2)母血和脐血中IL—6的关系:母血中IL—6值均
In various inflammatory reactions, interleukin-6 (IL-6) induces the production of various acute phase proteins in hepatocytes and emerges first, making early diagnosis of neonatal infections possible. Subjects and Methods 244 newborns born in May-July 1990 were selected as subjects and 199 healthy children as control group, 57 of whom were over 38 ℃. From the umbilical cord after childbirth, blood samples were taken from the umbilical cord. In some cases, maternal peripheral blood was also collected. After that, serum was collected and maintained at -80 ° C. The concentration of IL-6 was measured by enzyme-linked immunosorbent assay. Results (1) IL-6 concentration in cord blood: The serum IL-6 in healthy children was mostly not high, only 1 case more than 5pg / ml (0.5%). Cord blood 5pg / ml or more accounted for 18%, of which 8 cases were 50pg / ml or more, (2) the relationship between maternal blood and cord blood IL-6: IL-6 values in maternal blood were