黄曲霉毒素引起恒河猴胆管癌

• 作 者: 宋圃菊
• 出 处: 国外医学参考资料(卫生学分册)
• 发表日期: 1976年03期
• 关键词: 胆管癌 黄曲霉毒素 恒河猴 肌肉注射 活体检查 肝门 楔形 肝细胞癌 第一年 鳞状细胞癌

雌恒河猴一只给黄曲霉毒素(下简称AFT)5年半,然后观察5年3个月,猴发生胆管癌。1963年开始实验,猴重2.0公斤。给以结晶AFT(B_144%,G_144%,B_2与G_22%),第一年的第一个月,每天肌肉注射50微克,每周5天,其后的11个月,剂量改为100微克,仍为肌肉注射,每周5天。剩余的54个月,改为口服,剂量每天100微克,每周5天。此后不再给毒,继续观察。在观察期间定期针刺取肝活体检查。于1971年10月做楔形开放手术检

Female rhesus monkeys aflatoxin (AFT) for 5 years and a half, and then observed 5 years and 3 months, the occurrence of cholangiocarcinoma monkey. Experiment started in 1963, the monkey weighs 2.0 kg. To give crystalline AFT (B_144%, G_144%, B_2 and G_22%), the first month of the first year, intramuscular injection of 50 micrograms per day for 5 days, the next 11 months, the dose was changed to 100 micrograms, Still intramuscular injection, 5 days a week. The remaining 54 months, changed to oral doses of 100 micrograms per day, 5 days a week. No longer give poison, continue to observe. Regular acupuncture during the observation period for liver biopsy. In October 1971 to do wedge open surgery seized