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Flanagan(1966)发现一种裸鼠(Nude Mouse),当时认为是由于劣性遗传所致的突然变异鼠。Pantelouris(1968)证明此鼠是一种先天性无胸腺鼠。因为没有胸腺,所以细胞免疫功能不全,对感染的抵抗力减弱,自家免疫现象得到促进,对异体组织排斥现象消失。胸导管的淋巴液中存有T细胞和B细胞,虽经胸腺摘出的小鼠,仍残存相当多的T细胞,而裸鼠则完全无T细胞。裸鼠生后两周内大部死亡,如不死亡也无繁殖能力。如果生后在无菌条件下饲喂,则有可能长期存活,并有繁殖能力。作者将裸鼠在无菌条件下饲养。采取复发瘤型麻风患者的三个麻风结
Flanagan (1966) found a Nude Mouse, a sudden mutant mouse thought to be due to poor inheritance. Pantelouris (1968) proved that this mouse is a congenital athymic rat. Because there is no thymus, so cellular immune dysfunction, reduced resistance to infection, self-immune phenomenon has been promoted, the exclusion of allogeneic tissue disappeared. There are T cells and B cells in the thoracic duct lymphoid tissue. Although the mice that have been excised through the thymus still have quite a lot of T cells remaining, the nude mice have no T cells at all. Most nude mice died within two weeks after birth, if no death nor reproductive capacity. If born after aseptic feeding conditions, it is possible to long-term survival, and have the ability to reproduce. The nude mice were aseptically housed. Take three leprosy knots in patients with recurrent tumorous leprosy