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1986～1992年间共收治儿童晚期神经母细胞瘤22例,女13例,男9例,中数年龄为2.92岁(11月至9岁),原发瘤位于腹膜后的18例,胸腔4例。Ⅲ期2例,ⅣA期16例,ⅣB期4例,其中12例伴有骨髓转移,检测的16例中有8例N-myc癌基因扩增阳性(30～100个拷贝)。在进行骨髓移植时,18例处于部分缓解,2例未缓解。 对全部病人首先用A1原方案化疗,即环磷酸胺1200mg/m~2,6/小时内输完,用1天;长春新碱1.5mg/m~2,第1天;四氢吡喃阿霉
Between 1986 and 1992, 22 children with advanced neuroblastoma were enrolled, 13 were female and 9 were males. The median age was 2.92 years (range from 11 months to 9 years). There were 18 cases of primary tumor in the retroperitoneum and 4 cases of pleural cavity . There were 2 cases of stage Ⅲ, 16 cases of stage ⅣA and 4 cases of stage ⅣB, of which 12 cases were associated with bone marrow metastasis. Among 16 cases detected, 8 cases had a positive amplification of 30-100 copies of N-myc oncogene. In the bone marrow transplantation, 18 patients were partially relieved, 2 patients did not relieve. For all patients first with the A1 original regimen of chemotherapy, that is, cyclophosphamide 1200mg / m ~ 2,6 / h lose, with 1 day; vincristine 1.5mg / m ~ 2, the first day; tetrahydropyran mold