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以放射免疫学方法对赞皇县胃癌高发区1504名成年居民血清胃蛋白酶原(PG)Ⅰ、Ⅱ和胃泌素(GAS)水平进行了定量分析,同时以ELISA方法对血清幽门螺杆菌(Hp)抗体进行了检测。研究结果发现农村居民血清PGⅠ、PGⅡ和GAS均明显偏离正态分布。赞皇县农村成年居民Hp感染均比较普遍 ,血清Hp抗体阳性率达到66.4%。内窥镜和病理学检查证实,血清PG异常居民的胃粘膜91%以上可见癌前病变。提示血清PG异常的居民是胃癌的高危人群,血清PG异常可作为胃癌前病变的筛查指标
The levels of serum pepsinogen (PG) Ⅰ, Ⅱ and gastrin (GAS) in 1504 adult residents in Zanhuang County were detected by radioimmunoassay. Serum Helicobacter pylori (Hp) ) Antibody was detected. The results showed that rural residents serum PG Ⅰ, PG Ⅱ and GAS were significantly deviated from the normal distribution. Huanhuang adult residents in rural Zanhuang are more common, the positive rate of serum Hp antibody reached 66.4%. Endoscopy and pathological examination confirmed that more than 91% of the residents with abnormal serum PG gastric mucosa can be seen precancerous lesions. Suggesting that abnormal serum PG is a high risk population of gastric cancer, serum PG abnormalities can be used as a screening indicator of gastric precancerous lesions