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目的探讨白细胞介素4(IL-4)及受体(IL-4R)基因多态性与维吾尔族人群(维族)变应性鼻炎的关联。方法采用人群为基础的病例对照研究成组设计,选择新疆喀什地区维族变应性鼻炎(AR)患者109例为病例组,以同居住地、同民族、同性别作为匹配条件,选取393例非AR居民为对照组。采用聚合酶链反应-限制性片段长度多态性法(PCR-RFLP)检测IL-4rs2243283C/G和IL-4R rs6498011A/G位点基因多态性,比较其在病例组与对照组间基因型和等位基因的频率分布。结果 IL-4R基因rs6498011A/G位点在病例组和对照组间基因型和等位基因型分布频率差异有统计学意义(P=0.008)。IL-4基因rs2243283C/G位点在两组间分布差异无统计学意义(P=0.999)。结论 IL-4Rrs6498011A/G位点与维族变应性鼻炎密切相关。
Objective To investigate the association between polymorphisms of IL-4 and IL-4R and Uygur ethnic (Uygur) allergic rhinitis. Methods A population-based case-control study was conducted in a group design. 109 cases of Uygur allergic rhinitis (AR) in Xinjiang Kashgar region were selected as the case group and 393 non-AR Residents for the control group. The gene polymorphisms of IL-4 rs2243283C / G and IL-4R rs6498011A / G were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and compared with the genotype And the allele frequency distribution. Results There was a significant difference in genotype and allele frequency between rs6498011A / G locus and control group (P = 0.008). The rs2243283C / G locus of IL-4 gene was not significantly different between the two groups (P = 0.999). Conclusion IL-4R rs6498011A / G locus is closely related to Uygur allergic rhinitis.