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目的探讨HBV感染者血清pre-S1Ag、pre-S1Ag联合HBe Ag与HBV感染传统标志物之间的关系,以评价其在临床诊疗中的作用。方法采用ELISA法对373例HBV感染者pre-S1Ag及HBV血清标志物进行检测,采用FQ-PCR法对HBV DNA进行平行检测。结果 373例HBV感染者中,HBe Ag、pre-S1Ag、pre-S1Ag联合HBe Ag检测与HBV DNA的总符合率分别为54.4%、75.1%、85.8%;158例HBe Ag阳性血清中,HBV DNA与pre-S1 Ag的阳性率分别为87.3%、68.4%,差异有统计学意义(P<0.05);215例HBe Ag阴性血清中,HBV DNA与pre-S1Ag的阳性率分别为69.8%、61.9%,差异无统计学意义(P>0.05);pre-S1Ag联合HBe Ag阳性率随乙肝感染者病程进展呈上升趋势。结论 pre-S1Ag能很好地反映体内HBV复制情况,其阳性率与HBV DNA具有较高的一致性;且pre-S1Ag联合HBe Ag检测阳性率与乙肝感染者病程进展密切相关,能适时地指导临床根据患者病情针对性地治疗。
Objective To investigate the relationship between serum HBV pre-S1Ag, pre-S1Ag and HBeAg in HBV infected patients and traditional markers of HBV infection in order to evaluate its role in clinical diagnosis and treatment. Methods 373 HBV-infected pre-S1Ag and HBV serum markers were detected by ELISA. HBV DNA was detected by FQ-PCR in parallel. Results The total coincidence rates of HBeAg, pre-S1Ag and HBeAg with HBV DNA were 54.4%, 75.1% and 85.8% respectively in 373 cases of HBV infection. In 158 cases of HBe Ag positive serum, HBV DNA And pre-S1 Ag were 87.3% and 68.4%, respectively (P <0.05). The positive rates of HBV DNA and pre-S1Ag in 215 HBeAg-negative sera were 69.8% and 61.9 %, The difference was not statistically significant (P> 0.05). The positive rate of pre-S1Ag combined with HBe Ag increased with the progression of hepatitis B infection. Conclusion Pre-S1Ag can well reflect HBV replication in vivo, and its positive rate is highly consistent with that of HBV DNA. The positive rate of pre-S1Ag combined with HBeAg detection is closely related to the course of hepatitis B virus infection and can guide timely Clinical treatment according to the patient’s condition targeted.