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皮肤上共生的微生物群体有着很高的多样性,这个群体的组成会随着时间推移而发生改变。美国国家过敏和传染病研究所Belkaid博士的研究小组发现,小鼠全身外涂表皮葡萄球菌后可长期影响皮肤表面的菌落构成,并诱导皮肤的IL-17A及IFN-γ生成。将表皮葡萄球菌小鼠耳廓外涂和皮下注射两种方式进行比较,2周后发现只有外涂可引起IL-17A的增加,同时皮下的其他炎性细胞如中性粒细胞和单核细胞及其他炎症因子没有增加,推测这种外涂共生菌引起的反应与炎症无关。如
The microbial communities that live together on the skin are highly diverse and the composition of this group changes over time. The team from the National Institute of Allergy and Infectious Diseases, Belkaid, found that systemic administration of Staphylococcus epidermidis to mice permanently affected colony formation on the skin surface and induced IL-17A and IFN-γ production in the skin. Two weeks after topical application of epidermal S. aureus to the auricular and subcutaneous injection, two weeks later, only topical application of IL-17A resulted in an increase in IL-17A while subcutaneous other inflammatory cells such as neutrophils and monocytes And other inflammatory factors did not increase, speculated that the application of commensal bacteria caused by the reaction has nothing to do with inflammation. Such as