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母体胚胎亮氨酸拉链激酶(MELK)是一种Ser/Thr蛋白激酶,也是一种细胞周期依赖性蛋白激酶,属于蔗糖非发酵-1/AMP活化蛋白激酶(Snf1/AMPK)家族。最近研究发现,MELK在许多肿瘤细胞中表达水平增高,其高表达能够抑制肿瘤细胞及某些干细胞的分化与凋亡,并促进肿瘤细胞增殖,与许多恶性肿瘤的不良预后密切相关,被认为是一种原癌基因。此外,MELK参与多种信号通路调控,促进细胞增殖和肿瘤形成。MELK沉默有望成为肿瘤新的治疗靶点之一。本文就MELK的结构、功能、表达调控及与胃肠道肿瘤关系的研究进展作一综述。
The maternal embryo leucine zipper kinase (MELK) is a Ser / Thr protein kinase and a cell cycle-dependent protein kinase belonging to the family of sucrose non-fermenting-1 / AMP-activated protein kinase (Snf1 / AMPK). Recent studies found that MELK expression increased in many tumor cells, the high expression of tumor cells and some stem cells can inhibit the differentiation and apoptosis, and promote tumor cell proliferation, and many malignant tumors is closely related to the poor prognosis, is considered to be A proto-oncogene. In addition, MELK is involved in the regulation of various signaling pathways, promoting cell proliferation and tumorigenesis. MELK silencing is expected to become one of the new therapeutic targets for cancer. This review summarizes the research progress on the structure, function, expression and regulation of MELK and its relationship with gastrointestinal tumors.