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〔目的〕分析2006—2008年在北京国际旅行卫生保健中心体检的全部出境人员和部分社会体检人员乙型肝炎病毒(HBV)感染情况及乙型肝炎血清标志物的感染模式特征。〔方法〕用酶联免疫吸附试验(ELISA)测定乙型肝炎病毒五项血清标志物。〔结果〕在157627名体检人员中,乙型肝炎血清标志物有11种感染模式,一项或一项以上阳性者共18076例,感染率11.468%;其中31～40岁年龄段阳性者最多为4746例,阳性率为3.011%;全部阴性139551例,占总数的88.532%。HBsAg阳性有4种组合模式共3629人,检出率2.302%;HBsAb阳性有4种组合模式共4528例,检出率2.873%;HBeAg阳性有2种组合模式660例,检出率0.419%;HBeAb阳性有4种组合模式共5483例,检出率3.478%;HBcAb阳性有8种组合模式共14533例,检出率9.220%;小三阳2342例,检出率为1.486%;单纯HBcAb阳性者7112例,检出率为4.512%;单纯HBsAb阳性者3319例,检出率为2.106%。〔结论〕在北京国际旅行卫生保健中心体检人员中,乙肝感染率明显低于全国平均水平,乙肝血清标志物全部阴性者比例较高,提示加强这一群体的乙型肝炎免疫与检测工作十分重要。
[Objective] To analyze the infection status of Hepatitis B virus (HBV) and the pattern of infection of Hepatitis B serum markers in all outbound medical personnel and some social medical personnel who were inspected in Beijing International Travel Health Care Center from 2006 to 2008. [Methods] Five serological markers of hepatitis B virus were determined by enzyme-linked immunosorbent assay (ELISA). Results Among 157627 medical staffs, there were 11 infection patterns of hepatitis B serum markers, with a total of 18076 cases with one or more positives, the infection rate was 11.468%. Among them, the highest positive rate was 31-40 years old 4746 cases, the positive rate was 3.011%; all negative 139,551 cases, accounting for 88.532% of the total. There were 4,829 HBsAg positive modes with a detection rate of 2.302%. There were 4528 HBsAb positive modes with a detection rate of 2.873%. There were 2 types of HBeAg positive modes with a detection rate of 0.419%. There were 5483 cases of HBeAb positive and the detection rate was 3.478%. There were 8,533 cases of HBcAb positive, with a detection rate of 9.220% and 2342 cases of small Sanyang with a detection rate of 1.486%. HBcAb-positive patients 7112 cases, the detection rate was 4.512%; simple HBsAb positive 3319 cases, the detection rate was 2.106%. [Conclusion] Among the medical staff of Beijing International Travel Health Care Center, the infection rate of hepatitis B was significantly lower than the national average, and the proportion of all the hepatitis B serum markers was negative, suggesting that it is very important to strengthen this group of hepatitis B immunization and detection .