类癌及结肠癌、肺癌中神经内分泌细胞免疫组织化学研究

• 作 者: 黄孝立 杜晓光 李靖若 巩永杰 李淑云
• 机 构: 河南医科大学一附院病理科,河南医科大学一附院病理科,河南医科大学一附院病理科,河南医科大学一附院病理科,河南医科大学一附院病理科 进修生,进修生
• 出 处: 河南肿瘤学杂志
• 发表日期: 1993年02期
• 关键词: 类癌 结肠癌 神经内分泌细胞 结肠腺癌 组织发生学 小细胞肺癌 免疫组织化学 鳞癌 免疫化学 肺小细胞癌

应用铬粒素 A、NSE、S-100蛋白及 Leu7单克隆抗体免疫组织化学方法,对24例结肠癌和肺癌、8例类癌、4例小细胞肺癌进行研究,结果表明除类癌外,结肠腺癌和肺癌中也存在神经内分泌细胞,阳性率为铬粒素 A 20.8%(5/24 3,NSE 33%(8/24),S-100蛋白33%(8/24),Len7 12.5%(3/24)。探讨了神经内分泌源性肿瘤与结肠癌、肺癌之间的关系和组织发生学。初步提出了类癌可能起源于壁内内分泌细胞,但须进一步研究和证实。

Using chromogranin A, NSE, S-100 protein and Leu7 monoclonal antibody immunohistochemistry, 24 cases of colon cancer and lung cancer, 8 cases of carcinoid, and 4 cases of small cell lung cancer were studied. The results showed that in addition to carcinoid, Neuroendocrine cells were also present in colon adenocarcinoma and lung cancer. The positive rates were 20.8% for chromogranin A (5/24 3, 33% for NSE, 8/24), 33% for S-100 protein (8/24), and Len7 12.5. % (3/24).Discussed the relationship between neuroendocrine tumors and colon cancer, lung cancer, and histogenesis.Preliminously proposed that carcinoid may originate from intramural endocrine cells, but further study and confirmation are needed.