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目的:观察C反应蛋白(CRP)在儿童急性白血病合并医院感染患者中的变化及其临床意义。方法:采用免疫透射比浊法测定70例急性白血病患儿及15例健康体检者(对照组)的血清CRP含量,分析CRP水平与病情预后的关系。结果:急性白血病患儿在未发生医院感染的情况下,化疗前后血清CRP值与对照组相比,无显著变化(P>0.05),而合并医院感染的患儿,其CRP值显著高于对照组(P<0.01),而且,全身炎症反应综合征组明显高于呼吸道感染组(P<0.01)。结论:CRP可以作为儿童急性白血病合并医院感染早期诊断的实验室指标之一,同时动态观察CRP值的变化有助于及时判断病情变化和预后。
Objective: To observe the changes and clinical significance of C-reactive protein (CRP) in childhood acute leukemia with nosocomial infection. Methods: Serum CRP levels in 70 children with acute leukemia and 15 healthy controls (control group) were determined by immunoturbidimetry. The relationship between CRP level and prognosis was analyzed. Results: In the absence of nosocomial infection, serum CRP in patients with acute leukemia had no significant change (P> 0.05) before and after chemotherapy, but CRP in children with nosocomial infection was significantly higher than that in control (P <0.01). Moreover, the systemic inflammatory response syndrome group was significantly higher than the respiratory tract infection group (P <0.01). Conclusion: CRP can be used as one of the laboratory indexes for the early diagnosis of childhood acute leukemia complicated with nosocomial infection. Simultaneously, the dynamic observation of the change of CRP value can help to judge the change of disease and prognosis in time.