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目的:探讨糖尿病肾病不同进展阶段的微炎症状态,并分析益肾化湿颗粒对糖尿病肾病不同阶段微炎症状态的影响。方法:选取我院在2014年5月~2016年4月收治的86例糖尿病肾病患者进行研究,采用随机数字法将86例患者平均分为两组,每组均有43例患者。给予对照组患者常规干预手段,控制患者血糖及血压;观察组则在对照组患者基础上给予益肾化湿颗粒药物进行干预治疗,分析两组患者在不同进展阶段的微炎症状态,并判断干预治疗效果。结果:(1)两组患者疾病在不同进展阶段微炎症状态呈现出明显差异(P<0.05);(2)干预治疗后,两组患者微炎症因子差异明显,观察组患者微炎症因子(IL-6、hsCRP以及TNF-a)水平均显著低于对照组患者,具有统计学意义(P<0.05)。结论:糖尿病肾病患者随着病程的进展,微炎症状态更加严重,在控制患者血糖及血压的基础上,联合使用益肾化湿颗粒有助于改善糖尿病肾病肾功能,抑制微炎症状态。
Objective: To investigate the status of microinflammation during different stages of diabetic nephropathy and to analyze the influence of YISHENHUA MOI granule on the micro-inflammatory state in different stages of diabetic nephropathy. Methods: Totally 86 patients with diabetic nephropathy who were treated in our hospital from May 2014 to April 2016 were enrolled. A total of 86 patients were divided into two groups according to the random number method. There were 43 patients in each group. The patients in the control group were given conventional interventions to control the blood sugar and blood pressure of the patients. The observation group was treated with Yishen Huashui Granules on the basis of the control group, and the microinflammatory state of the two groups was analyzed at different stages of progression. treatment effect. Results: (1) There was a significant difference in the state of microinflammation between the two groups (P <0.05). (2) After the intervention, there was significant difference in the micro-inflammatory factor between the two groups. The micro-inflammatory factor -6, hsCRP and TNF-a levels were significantly lower than the control group, with statistical significance (P <0.05). Conclusion: With the progress of diabetic nephropathy, the state of micro-inflammation is more serious. Combined with Yishen Huashui Granule can help to improve the renal function of diabetic nephropathy and inhibit the micro-inflammatory state on the basis of controlling the blood sugar and blood pressure of patients.