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目的 探讨慢性乙型肝炎患者肝组织过渡型CK19阳性表达细胞与肝癌前病变变的关系。方法 用LSAB免疫组化染色方法观察慢性乙型肝炎患者肝组织CK19的表达,并对患者每3个月检查B超和血清AFP,随访至1年。结果 肝组 织出现卵圆细胞分化为肝细胞的过渡型CK19阳性表达细胞的患者大多数出现血清AFP的明显升高,随访至1年,有1例患者出现小肝癌,1例出现肝实质低回声结节。结论 过渡型CK19阳性表达细胞可作为一种新的可能的肝癌前病变的病理学标志。
Objective To investigate the relationship between the transitional type CK19 positive cells and the precancerous lesions of liver cancer in patients with chronic hepatitis B. Methods The expression of CK19 in liver tissue of patients with chronic hepatitis B was observed by LSAB immunohistochemical staining. B - ultrasound and serum AFP were examined every 3 months in patients with chronic hepatitis B and were followed up for 1 year. Results Most of patients with transitional CK19 positive cells with oval cells differentiated into hepatocytes in liver showed a significant increase in serum AFP. One patient developed small hepatocellular carcinoma at one year follow-up, and one patient had low echo of liver parenchyma Nodules. Conclusions Transitional CK19 positive cells can be used as a new pathological marker of precancerous lesions of hepatocellular carcinoma.