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目的探讨米非司酮联合依沙吖啶在孕16～24w(胎儿畸形)引产中的使用价值。方法选择临床上B超提示胎儿畸形自愿要求终止16～24w妊娠的健康妇女228例,随机分成实验组114例,对照组114例。实验组在口服米非司酮50mg,以后每12h给药一次,共200mg,最后一次给药后立即行依沙吖啶羊膜腔内穿刺术,注入依沙吖啶100 mg。对照组直接行依沙吖啶羊膜腔内穿刺术,注入依沙吖啶100 mg。结果实验组和对照组子宫腔内注药至宫缩开始时间分别为22.8±4.9h和23.2±5.1h;产程为4.3±1.7h和13.8±4.5h;平均胎盘娩出时间为3.1±1.9min和10.3±5.2min;产后出血量为48±21ml和112±19ml;产后刮宫率实验组24例,对照组98例,两组存在显著性差异(P<0.05=,两组平均产后出血时间及流产后首次月经情况无显著性差异(P>0.05)。结论两组自羊膜腔注药到宫缩开始时间无显著差异,但联合用药明显缩短产程及胎盘娩出时间,且明显减少产时产后出血量及流产后刮宫率,是一种较为理想的中期引产方法,引产成功率可达100%。
Objective To investigate the value of mifepristone combined with ethacridine in induction of labor during 16 ~ 24 weeks pregnant (fetal malformation). Methods A total of 228 healthy women who voluntarily demanded to terminate pregnancy during 16 ~ 24 weeks were enrolled in this study. They were randomly divided into experimental group (114 cases) and control group (114 cases). Experimental group oral mifepristone 50mg, after every 12h dosing, a total of 200mg, immediately after the last administration according to enamel amniocentesis puncture, injection of ethacridine 100 mg. In the control group, they were directly injected with amniotic fluid into the amniotic cavity to inject 100 mg of ethacridine. Results The intrauterine injection to uterine contractions in experimental group and control group were 22.8 ± 4.9h and 23.2 ± 5.1h respectively; the duration of labor was 4.3 ± 1.7h and 13.8 ± 4.5h; the mean placenta delivery time was 3.1 ± 1.9min and 10.3 ± 5.2min; postpartum hemorrhage 48 ± 21ml and 112 ± 19ml; postpartum curettage rate in the experimental group 24 cases, 98 cases in the control group, there were significant differences between the two groups (P <0.05 = average postpartum hemorrhage time and abortion (P> 0.05) .Conclusion There was no significant difference between the two groups in starting time of contractions from the amniotic cavity injection, but the combination therapy significantly shortened labor and placental delivery time, and significantly reduced the amount of postpartum hemorrhage And post-abortion curettage rate, is an ideal mid-term induction of labor, induction of labor success rate of up to 100%.