论文部分内容阅读
目的探讨瘤原性骨软化症(TIO)临床特征、影像学特征及治疗方法。方法回顾性分析15例TIO患者的临床资料,分析其临床表现、血磷、尿磷及药物治疗情况。结果患者血磷在肿瘤切除后当日即见升高,术后第1~3天逐渐升高。12例于术后1周恢复正常或基本正常。2例合并甲状旁腺瘤血磷虽升高,但未恢复至正常。13例患者在肿瘤切除术后骨痛、关节痛等临床症状随着血磷含量增加而逐渐减轻,随访期间未复发。1例恶性血管内皮瘤、1例腱鞘巨细胞瘤随访期间复发。结论瘤原性骨软化症在切除肿瘤后血磷升高,症状明显改善,但其诊断及定位诊断较困难。
Objective To investigate the clinical features, imaging features and treatment of tumorous osteomalacia (TIO). Methods The clinical data of 15 TIO patients were retrospectively analyzed. The clinical manifestations, serum phosphorus, urinary phosphate and drug treatment were analyzed. Results Patients with phosphorus in the day after tumor resection that see the rise, gradually increased after 1 to 3 days. Twelve cases returned to normal or almost normal one week after operation. 2 cases of parathyroid adenoma with elevated serum phosphorus, but did not return to normal. Thirteen patients suffered from pain, arthralgia and other clinical symptoms after tumor resection with the increase of serum phosphorus gradually reduced, no recurrence during follow-up. One case of malignant hemangioendothelioma and one case of tendonoid giant cell tumor recurred during follow-up. Conclusion Oophoroma osteomalacia increases the serum phosphorus after resection of the tumor, and the symptoms are obviously improved. However, it is difficult to diagnose and locate the tumor.