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目的探讨胃癌患者围术期外周血T淋巴和免疫球蛋白的水平的变化规律。方法选取2009年11月～2011年12月于某院进行胃癌手术的78例患者为观察组,同期的78名健康人为对照组,将对照组和观察组术前、术后3d、7d的外周血T淋巴和免疫球蛋白水平进行检测及比较。结果观察组术前及术后3d、7d的CD3+、CD4+、CD4/CD8及IgA、IgM、IgG均先降后升,CD8+先升后降,开腹手术患者术后7d与对照组相比差异有统计学意义,P均﹤0.05,而腹腔镜手术患者与对照组相比差异无统计学意义,P均﹥0.05。结论胃癌患者围术期外周血T淋巴和免疫球蛋白的水平的变化规律对于了解疾病的发展转归有着积极的作用,且对于术式的选择也有一定的指导意义。
Objective To investigate the changes of perioperative peripheral blood T lymphoid and immunoglobulin levels in patients with gastric cancer. Methods 78 patients with gastric cancer who underwent surgery in a hospital from November 2009 to December 2011 were selected as the observation group and 78 healthy persons as the control group during the same period. The control group and the observation group were divided into two groups: preoperative, postoperative 3d and postoperative 7d Blood T lymphocytes and immunoglobulin levels were detected and compared. Results The levels of CD3 +, CD4 +, CD4 / CD8, IgA, IgM and IgG in the observation group decreased first and then decreased, and the levels of CD8 + increased first and then decreased in the observation group at 7 and 7 days after operation. Compared with the control group, There was statistical significance, P <0.05, while laparoscopic surgery patients compared with the control group no significant difference, P> 0.05. Conclusion The changes of perioperative peripheral blood T lymphocytes and immunoglobulins in patients with gastric cancer have a positive effect on understanding the development of the disease and are of guiding significance for the choice of surgical procedures.