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滤泡辅助性T细胞(Tfh)是新型的CD4+辅助性T细胞,促进了生发中心的形成和维持,促使B细胞增殖、抗体类别转换,以及分化成为浆细胞和记忆性B细胞。参与Tfh细胞功能的主要分子包括:CXCR5、诱导性共刺激分子(ICOS)、CD40L和程序性死亡-1分子(PD-1)。IL-21是其主要的效应因子。Tfh在免疫相关性消化系统疾病(如炎症性肠病、自身免疫性肝病)以及感染性疾病(如慢性病毒性肝炎)等的发病中其中一定的作用。本文就此作一综述。
Follicular helper T cells (Tfh) are novel CD4 + helper T cells that promote germinal center formation and maintenance, promote B cell proliferation, convert antibody classes, and differentiate into plasma cells and memory B cells. Major molecules involved in Tfh cell function include CXCR5, inducible costimulatory molecule (ICOS), CD40L and PD-1. IL-21 is its major effector. Tfh plays a role in the pathogenesis of immune-related digestive diseases such as inflammatory bowel disease, autoimmune liver disease and infectious diseases such as chronic viral hepatitis. This article gives a summary of this.