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背景:三磷酸胞苷(cytridinitriphosphatis,CTP)主要用于脑血管意外及其后遗症,脑震荡,脑血管硬化,老年性痴呆等的治疗,而该药对糖尿病周围神经病变的作用又如何呢?目的:观察CTP改善糖尿病周围神经病变患者神经功能作用,并评价该药作用效果及神经电生理作用。设计:以患者为研究对象,前瞻性随机对照设计的验证性实验研究。单位:第四军医大学医院内分泌科病房。对象:1999-09/2000-02在第四军医大学西京医院内分泌科住院的糖尿病周围神经病变患者50例,符合纳入标准糖尿病周围神经病变患者50例,男28例,女22例。将50例患者随机分为治疗组和对照组各25例,均知情同意。方法:治疗组25例用CTP60mg加入生理盐水100mL维生素D,1次/d。对照组25例用维生素B1100mg和维生素B12500μg,1次/d,东莨菪碱(654-2)20mg加入生理盐水100mL维生素D,1次/d,疗程均为14d。神经传导速度采用的是表面电极顺行性测定。主要观察指标:两组患者肢体神经传导速度。结果:治疗组患者经过CTP治疗14d后,双上肢及下肢正中神经、尺神经、腓总神经、胫神经传导速度明显高于对照组(P<0.05～0.01)。治疗组患者经过三磷酸胞苷14d治疗后,神经症状、神经体征评分(1.4±0.5,3.0±0.5)明显低于对照组(2.6±0.3,4.0±0.3)(t=3.255,2.005,P<0.05)。结论:三磷?
Background: cytridinitriphosphatis (CTP) is mainly used for the treatment of cerebrovascular accident and its sequelae, concussion, cerebrovascular sclerosis and Alzheimer’s disease, etc. What is the effect of this medicine on diabetic peripheral neuropathy? To observe the effect of CTP on neurological function in patients with diabetic peripheral neuropathy and to evaluate the effect of the drug and neuroelectrophysiology. Design: A pilot study of prospective, randomized, controlled design of patients. Unit: Fourth Military Medical University Hospital Endocrinology Ward. PARTICIPANTS: Fifty patients with diabetic peripheral neuropathy hospitalized in Department of Endocrinology, Xijing Hospital, Fourth Military Medical University from September 1999 to February 2000 were enrolled in this study. Fifty patients with standardized peripheral neuropathy were included, 28 males and 22 females. Fifty patients were randomly divided into treatment group and control group of 25 cases, all with informed consent. Methods: 25 cases of treatment group with CTP60mg added saline 100mL vitamin D, 1 / d. Control group, 25 cases with vitamin B1100mg and vitamin B12500μg, 1 / d, scopolamine (654-2) 20mg added saline 100mL vitamin D, 1 / d, treatment were 14d. Nerve conduction velocity is measured by the surface electrode. MAIN OUTCOME MEASURES: Rate of limb nerve conduction in two groups. Results: After treatment with CTP for 14 days, the conduction velocity of the median nerve, ulnar nerve, common peroneal nerve and tibial nerve in both upper extremities and lower extremities was significantly higher in the treatment group than that in the control group (P <0.05 ~ 0.01). Neurological symptoms and neurological symptom score (1.4 ± 0.5,3.0 ± 0.5) were significantly lower in the treatment group than those in the control group (2.6 ± 0.3, 4.0 ± 0.3) (t = 3.255, 2.005, P < 0.05). Conclusion: Triphosphorus?