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目的:探讨氨溴索治疗对慢性阻塞性肺疾病急性加重期(AECOPD)患者肺功能、氧化应激和炎症因子的影响。方法:选择我院收治的AECOPD患者90例,根据就诊先后顺序单双号分为观察组和对照组,每组45例,所有患者均给予常规对症治疗,在此基础上,观察组采用氨溴索治疗,连续治疗10d。分别于治疗前后检测肺功能指标:用力肺活量(FVC)、1秒用力呼气容积(FEV1)、1秒用力呼气容积占用力肺活量比值(FEV1/FVC),血清氧化应激指标:丙二醛(MDA)、超氧化物歧化酶(SOD)和血清炎症因子:白细胞介素-6(IL-6)、白细胞介素-10(IL-10)以及肿瘤坏死因子-α(TNF-α)的水平变化。结果:观察组治疗后肺功能指标FEV1、FVC、FEV1/FVC较本组治疗前以及对照组治疗后均明显升高(P<0.05);观察组治疗后氧化应激指标MDA均较治疗前和对照组治疗后明显降低,SOD较治疗前和对照组治疗后明显升高,差异有统计学意义(P<0.05);观察组治疗后促炎因子IL-6、TNF-α均较治疗前和对照组治疗后明显降低,抗炎因子IL-10较治疗前和对照组治疗后明显升高,差异有统计学意义(P<0.05)。结论:氨溴索可明显降低AECOPD患者的炎症反应,对患者氧化应激及肺功能具有明显改善作用,具有积极的临床意义。
Objective: To investigate the effects of ambroxol on pulmonary function, oxidative stress and inflammatory factors in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: AECOPD patients admitted to our hospital 90 cases, according to the order of treatment were single and double numbers were divided into observation group and control group, 45 cases in each group, all patients were given conventional symptomatic treatment, on this basis, the observation group with ammonia bromine Cable treatment, continuous treatment 10d. Before and after treatment, the indexes of pulmonary function were measured: forced vital capacity (FVC), forced expiratory volume in one second (FEV1), forced expiratory volume in one second (FEV1 / FVC), serum oxidative stress index MDA, SOD and serum IL-6, IL-10 and TNF-α Horizontal changes. Results: After treatment, FEV1, FVC and FEV1 / FVC of the observation group were significantly higher than those of the control group before and after treatment (P <0.05) The levels of SOD, IL-6 and TNF-α in the observation group were significantly lower than those before treatment and after treatment in the control group (P <0.05) The control group was significantly lower after treatment, anti-inflammatory factor IL-10 than before treatment and control group was significantly higher after treatment, the difference was statistically significant (P <0.05). Conclusion: Ambroxol can significantly reduce the inflammatory response in patients with AECOPD, which has a significant improvement on oxidative stress and pulmonary function in patients with active clinical significance.