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多种骨髓病的免疫异常屡有报道,最近,已有慢粒-单时单克隆丙种球蛋白病或多克隆血清免疫球蛋白浓度增加的报道,但对骨髓增生异常综合征(MDS)的其他类型之免疫状况所知甚少.本文报道52例 MDS患者的免疫学所见。本组患者中,男39例,女13例;中数年龄分别为70.5岁与71岁;其中 RA 17例,RAS 10例,RAEB 7例,CMML 7例,RAEB-T11例.结果:半数患者伴免疫球蛋白异常:6例(11.5%)有单克隆血清免疫球蛋白成分:IgG/κ 3例,IgGλ1例,IgM/κ 2例(此2例分别有本-周蛋白尿与冷球蛋白血症)。17例(32.6%)患者有多克隆血清免疫
Various abnormalities in bone marrow disease have been reported frequently. Recently, there have been reports of CGRP or polyclonal serum immunoglobulin concentration increase, but other studies on myelodysplastic syndrome (MDS) other Type of immune status is poorly understood.This paper reports 52 cases of MDS immunological findings. Among the patients, there were 39 males and 13 females with the median age of 70.5 years and 71 years respectively, including 17 cases of RA, 10 cases of RAS, 7 cases of RAEB, 7 cases of CMML and 11 cases of RAEB-T.Results: With immunoglobulin abnormalities: 6 cases (11.5%) were monoclonal serum immunoglobulin components: IgG / κ 3 cases, IgG1 cases, IgM / κ2 cases (the two cases were bencyclinuria and cold globulin Serum). Seventeen patients (32.6%) had polyclonal serum immunization