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神经干细胞具有几乎无限的稳定扩增能力以及体外分化为多巴胺能神经元的能力,使之成为神经变性疾病移植治疗的重要细胞来源。神经干细胞可以在宿主脑内增殖、分化、迁移并与宿主神经组织整合。移植后的神经干细胞系在体内特定环境下可以自发地表达多巴胺能神经元的特性。可以通过刺激成年哺乳动物脑内终生存在的神经干细胞,使之在脑内增殖、迁移,并分化为多巴胺能神经元,与周围建立突触联系以治疗帕金森病。神经干细胞治疗帕金森病的前景是巨大的,但距临床应用尚有一定距离,仍需要包括动物实验在内的大量基础研究。
Neural stem cells have an almost unlimited capacity for stable expansion and the ability to differentiate into dopaminergic neurons in vitro, making them an important source of cells for the treatment of neurodegenerative diseases. Neural stem cells can proliferate, differentiate, migrate and integrate with the host nerve tissue in the host brain. Transplanted neural stem cell lines spontaneously express the characteristics of dopaminergic neurons in a specific environment in the body. By stimulating lifelong neural stem cells in the adult mammalian brain, they proliferate, migrate, and differentiate into dopaminergic neurons in the brain to establish synaptic connections with the surrounding parkinsonism. The prospects for neural stem cells in the treatment of Parkinson’s disease are enormous, but still far from clinical use, and substantial basic research, including animal experimentation, is still needed.