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合成了一种新的烟酸锰配合物,并通过红外光谱﹑热重差热分析﹑元素分析﹑化学分析等手段确定其结构与组成.应用溶解量热法,分别测定了四水氯化锰、烟酸和烟酸锰在常压,298.15 K,混合溶剂(VDMSO∶VEtOH∶V2 mol/L HCl=1∶1∶1)中的溶解焓,△s Hm[MnCl2·4H2O(s),298.15 K]=-(13.596±0.170)kJ·mol-1,△s Hm[2C6H5NO2(s),298.15 K]=(42.780±0.090)kJ·mol-1以及△s Hm[[Mn(C6H4NO2)2]·2H2O,298.15 K]=(15.936±0.070)kJ·mol-1.根据热化学原理求出了反应MnCl2·4H2O(s)+2C6H5NO2(s)=[Mn(C6H4NO2)2]·2H2O(s)+2HCl(g)+2H2O(l).在298.15 K时标准摩尔反应焓△r Hm(1)=(66.42±0.88)kJ·mol-1和配合物[Mn(C6H4NO2)2]·2H2O(s)的标准摩尔生成焓△f Hm[[Mn(C6H4-NO2)2]·2H2O(s),298.15 K]=-(1554.8±2.0)kJ·mol-1.应用TAM air热导式等温微量量热仪测定了烟酸锰配合物[Mn(C6H4NO2)2]·2H2O在301.15 K时对粟酒裂殖酵母细胞生长代谢的产热曲线,计算得到了粟酒裂殖酵母细胞生长速率常数k,最大放热功率时间tp以及总放热量Qtotal等热化学参数.实验结果表明,随着烟酸锰配合物浓度的增加,粟酒裂殖酵母细胞生长代谢速率常数k和总放热量Qtotal减少,即烟酸锰对粟酒裂殖酵母细胞有抑制作用.
A new manganese nicotinate complex was synthesized and its structure and composition were determined by means of IR, TG-DTA, elemental analysis and chemical analysis. The solubility calorimetry , The enthalpies of dissolution of niacin and manganese nicotinate at atmospheric pressure, 298.15 K, mixed solvent (VDMSO: VEtOH: V2 mol / L HCl = 1: 1: 1), △ s Hm [MnCl2 · 4H2O (s) (13.596 ± 0.170) kJ · mol -1, Δs Hm [2C6H5NO2 (s), 298.15 K] = (42.780 ± 0.090) kJ · mol- 1 and Δs Hm [[Mn (C6H4NO2) 2] · 2H2O, 298.15 K] = (15.936 ± 0.070) kJ · mol-1. According to the thermochemical principle, the reaction MnCl2 · 4H2O (s) +2 C6H5NO2 (s) = [Mn (C6H4NO2) 2] · 2H2O +2HCl (g) + 2H2O (l). The standard molar enthalpy of reaction, Δr Hm (1) = (66.42 ± 0.88) kJ · mol -1 at 298.15 K, and the complex [Mn (C6H4NO2) 2] ) Standard molar enthalpy of formation △ f Hm [[Mn (C6H4-NO2) · 2H2O (s), 298.15 K] = - (1554.8 ± 2.0) kJ · mol-1. The thermal curve of the growth and metabolism of Schizosaccharomyces pombe cells was determined by calorimetry at the concentration of Mn (C6H4NO2) 2] · 2H2O at 301.15 K, and the growth rate of S. pombe cells was calculated. k, the maximum exothermic power time tp and the total exothermic quantity Qtotal, etc. The experimental results show that the metabolic rate constant k and the total excretion Qtotal of Schizosaccharomyces pombe decreased with the increase of the concentration of nickel nicotinate , That is, nicotinic acid has an inhibitory effect on Schizosaccharomyces pombe cells.