【摘 要】
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Uranium removal efficacy of fullerence multi-macrocyclic polyamine derivatives (C60-MMP), a novel chelat-ing agent, was evaluated in mice. C60-MMP was administr
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Uranium removal efficacy of fullerence multi-macrocyclic polyamine derivatives (C60-MMP), a novel chelat-ing agent, was evaluated in mice. C60-MMP was administrated intravenously into mice at 30 min after the uranium contamination. The molar ratio of chelating ligand/uranium was about 1:1. The results indicate that C60-MMP can effectively prevent accumulation of uranium in liver at 8 h after C60-MMP injection. At 48 h af-ter the last injection, uranium deposition in liver of C60-MMP treated mice is approximately 65%less than that of the control group. C60-MMP reacted positively in promoting the removal of uranium from kidney, and the urinary uranium excretion increased significantly, compared with the control and DTPA-treated mice. However, repeated administration of C60-MMP, and combined injection of DTPA and C60-MMP, did not show desirable effects on uranium removal from mice. It implies that more investigations are needed for the treatment protocols and clinical applications of C60-MMP.
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